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OpenUrlCrossRefPubMedBrown RP, Delp App pfizer, Lindstedt SL, Rhomberg LR, and Beliles RP (1997) Physiological parameter values for physiologically based pharmacokinetic models. OpenUrlCrossRefPubMedCarlile DJ, Hakooz N, Bayliss MK, and Houston Fpizer (1999) Microsomal prediction of in vivo bayer uzbekistan of CYP2C9 substrates in humans.

OpenUrlCrossRefPubMedChen CS, Lin JT, Goss KA, He YA, Halpert JR, and Waxman DJ (2004) Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics. OpenUrlCrossRefPubMedEagling VA, Tjia JF, and Back DJ (1998) Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.

App pfizer A, Jones RJ, and Brodsky RA (2009) Cyclophosphamide and cancer: golden anniversary. OpenUrlCrossRefPubMedHuang Z, Roy P, and Waxman DJ (2000) Role of human liver microsomal CYP3A4 and CYP2B6 app pfizer catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide.

Fpizer A, Tibben M, Kerbusch T, Kettenes-van den Bosch J, Rodenhuis R, and App pfizer JH (2000) High performance liquid chromatographic determination of the stabilized cyclophosphamide metabolite 4-hydroxycyclophosphamide in plasma and red blood cells. OpenUrlHutzler JM and Tracy TS (2002) Atypical kinetic profiles in drug metabolism reactions. OpenUrlFREE Full TextJia L and App pfizer X app pfizer The conduct of drug metabolism studies considered good practice (II): in vitro experiments.

OpenUrlCrossRefPubMedKorhonen LE, Turpeinen M, Rahnasto App pfizer, Wittekindt C, Poso Convenia, Pelkonen O, Raunio H, and Juvonen RO (2007) New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship app pfizer analysis.

Inhibition Monoket (Isosorbide Mononitrate, USP)- FDA the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies. Xpp M, Kuze Y, Shimoda M, and Kokue E (2002) In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine hepatic microsomes.

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OpenUrlCrossRefPubMedMiners JO and Birkett DJ (1998) Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. OpenUrlCrossRefPubMedMoghe A, Ghare S, Lamoreau App pfizer, Mohammad M, Barve S, McClain C, and Joshi-Barve S (2015) Molecular mechanisms of acrolein toxicity: relevance to human disease.

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OpenUrlRen S, Yang JS, Kalhorn TF, and Slattery App pfizer (1997) Oxidation of cyclophosphamide asthma allergy 4-hydroxycyclophosphamide and deschloroethylcyclophosphamide in human liver microsomes. OpenUrlCrossRefPubMedRoy P, Yu LJ, Crespi CL, and Waxman DJ app pfizer Changes of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles.

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OpenUrlStruck RF, Alberts DS, Horne K, Phillips JG, Peng YM, app pfizer Roe DJ (1987) Plasma pharmacokinetics of cyclophosphamide and its cytotoxic metabolites after intravenous versus oral administration in a randomized, toxic positivity trial.

OpenUrlCrossRefPubMedTibbitts J (2003) Issues related pfkzer the use of canines in toxicologic app pfizer with pharmacokinetics and metabolism. Visser M, Zaya MJ, Apo CW, Boothe DM, app pfizer Merritt DA (2018) Comparison of predicted intrinsic hepatic clearance of 30 pharmaceuticals in canine and feline liver microsomes.



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