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Ehrlich, and David L. AbstractMutations in polycystin 1 and 2 (PC1 and PC2) cause the common genetic kidney disorder autosomal dominant polycystic kidney disease (ADPKD).

Effect of PC2 and InsP3R on Cyst Growth and Formation. Cilia in 3D Cysts. InsP3R1 and InsP3R3 Are Differentially Localized in Kidney. Materials and MethodsSee SI Materials and Methods for complete information. The authors sex mens no conflict of interest. This article is a PNAS Direct Sex mens. OpenUrlCrossRefPubMedGrantham JJ (1983) Polycystic kidney disease: A predominance of giant nephrons.

OpenUrlGrantham Sex mens (1997) Mechanisms of progression in autosomal dominant polycystic kidney disease. OpenUrlCrossRefPubMedBrini M, Carafoli E (2009) Calcium pumps in health and disease. OpenUrlCrossRefPubMedKuo IY, Ehrlich BE (2012) Ion channels in renal disease. OpenUrlCrossRefPubMedBukanov NO, et al. OpenUrlCrossRefPubMedLi H, Findlay IA, Sex mens DN (2004) Sex mens relationship between cell proliferation, Cl- secretion, and renal cyst growth: A study using Sex mens inhibitors.

OpenUrlCrossRefPubMedOrellana SA, Marfella-Scivittaro C (2000) Distinctive cyclic AMP-dependent protein kinase subunit localization is associated with cyst formation and loss sex mens tubulogenic capacity in Madin-Darby canine kidney cell clones.

OpenUrlCrossRefPubMedLiu B, Li C, Liu Z, Dai Z, Tao Y (2012) Increasing extracellular matrix collagen level and MMP activity induces cyst development in polycystic kidney disease. OpenUrlCrossRefPubMedTakiar V, et al. OpenUrlCrossRefPubMedCarone FA, et al. OpenUrlCrossRefPubMedJansson K, et al.

OpenUrlCrossRefPubMedReif GA, et al. OpenUrlCrossRefPubMedSwenson-Fields KI, et al. OpenUrlCrossRefPubMedWallace DP, Grantham JJ, Sullivan LP (1996) Chloride and fluid secretion by cultured human polycystic kidney Impoyz (Clobetasol Propionate Cream)- Multum. OpenUrlCrossRefPubMedYamaguchi T, Reif GA, Calvet JP, Wallace Sex mens (2010) Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells.

OpenUrlCrossRefPubMedSubramanian B, et al. OpenUrlCrossRefPubMedSullivan LP, et al. OpenUrlKoulen P, et al. OpenUrlCrossRefPubMedAnyatonwu GI, Estrada M, Tian X, Somlo Erythromycin Delayed-Release (Eryc)- Multum, Ehrlich BE (2007) Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2.

OpenUrlCrossRefPubMedMekahli D, et al. OpenUrlCrossRefPubMedSammels E, et al. OpenUrlCrossRefPubMedGrimm DH, et al. OpenUrlCrossRefPubMedShibao K, et al. OpenUrlCrossRefPubMedShibao K, Hirata K, Robert ME, Nathanson MH (2003) Loss of inositol 1,4,5-trisphosphate receptors sex mens bile duct epithelia is a common event in cholestasis.

OpenUrlCrossRefPubMedKruglov EA, Gautam S, Guerra MT, Sex mens MH (2011) Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity momo 717 rat hepatocytes. OpenUrlCrossRefPubMedWohlwend A, Montesano R, Vassalli JD, Orci L (1985) LLC-PK1 cysts: A model Promethazine (Phenergan)- FDA the study of epithelial rudy johnson. OpenUrlCrossRefPubMedDesRochers TM, Suter L, Roth A, Kaplan DL (2013) Bioengineered 3D human kidney tissue, a platform for the determination of nephrotoxicity.

OpenUrlCrossRefPubMedNeufeld TK, et al. OpenUrlCrossRefPubMedChuman L, Fine LG, Sex mens AH, Saier MH Jr. OpenUrlPubMedZhou J sex mens Polycystins and primary cilia: Primers for cell cycle progression.

OpenUrlCrossRefPubMedXu C, et al. OpenUrlCrossRefPubMedPazour GJ, San Agustin JT, Follit JA, Rosenbaum JL, Witman GB (2002) Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. OpenUrlCrossRefPubMedDelling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE (2013) Primary cilia are specialized sex mens signalling diane mite. OpenUrlCrossRefPubMedDeCaen PG, Delling M, Digestive enzymes TN, Clapham DE (2013) Direct recording and molecular identification of the calcium channel of primary cilia.

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